Reproduction Abstracts

Introduction: Tone of glucocorticoid action in target organs is regulated by relative activity of 11βHSD type1 (11HSD1), a bidirectional oxidoreductase that mainly converts cortisone to active cortisol, and type 2 (11HSD2), an oxidase that inactivates cortisol to cortisone. We have demonstrated that bovine cumulus–oocyte complex (COC) expresses 11HSDs and both reductive and oxidative activities are present in COC undergoing IVM. In the present study we investigated r...